The Genomic Landscape of Severe Acute Respiratory Syndrome Coronavirus 2

Surveillance of Variants of Concern
      Severe acute respiratory syndrome coronavirus 2 variants or strains may have varying degrees of transmissibility, virulence, pathogenicity and response to vaccines.


      To read this article in full you will need to make a payment


      Subscribe to Advances in Molecular Pathology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


      1. Genomic surveillance for SARS-CoV-2 variants – CDC.
        (Available at:) (Accessed May 21, 2021)
      2. SAGE 89 minutes: coronavirus (COVID-19) response, 13 May 2021.
        in: Eighty-ninth SAGE meeting on COVID-19. 2021 (Available at:) (Accessed May 26, 2021)
        • Narang D.
        COVID-19: the second wave may not be the last – but which one will be? Science, the Wire.
        (Available at:) (Accessed May 24, 2021)
      3. Hyderabad SARS-CoV-2 serosurvey – Ministry of Science and Technology, Govt. of India, Council of Scientific and Industrial Research, Centre for Cellular and Molecular Biology.
        (Available at:) (Accessed May 26, 2021)
        • Sabino E.C.
        • Buss L.F.
        • Carvalho M.P.S.
        • et al.
        Resurgence of COVID-19 in Manaus, Brazil, despite high seroprevalence.
        Lancet. 2021; 397: 452-455
        • Fontanet A.
        • Cauchemez S.
        COVID-19 herd immunity: where are we?.
        Nat Rev Immunol. 2020; 20: 583-584
        • Nonaka C.K.V.
        • Franco M.M.
        • Gräf T.
        • et al.
        Genomic evidence of SARS-CoV-2 reinfection involving E484K spike mutation, Brazil.
        Emerg Infect Dis. 2021; 27: 1522-1524
        • Faria N.R.
        • Claro I.M.
        • Candido D.
        • et al.
        Genomic characterisation of an emergent SARS-CoV-2 lineage in Manaus: preliminary findings.
        Date: 2021
        • Cele S.
        • Gazy I.
        • Jackson L.
        • et al.
        Escape of SARS-CoV-2 501Y.V2 from neutralization by convalescent plasma.
        Nature. 2021; 593: 142-146
        • Shinde V.
        • Bhikha S.
        • Hoosain Z.
        • et al.
        • 2019nCoV-501 Study Group
        Efficacy of NVX-CoV2373 Covid-19 vaccine against the B.1.351 variant.
        N Engl J Med. 2021; 384: 1899-1909
        • Madhi S.A.
        • Baillie V.
        • Cutland C.L.
        • et al.
        • NGS-SA Group
        • Wits-VIDA COVID Group
        Efficacy of the ChAdOx1 nCoV-19 Covid-19 vaccine against the B.1.351 variant.
        N Engl J Med. 2021; 384: 1885-1898
      4. Global sequencing coverage, COVID-19 CoV genetics, enabled by data from GISAID.
        (Available at:) (Accessed May 23, 2021)
        • Cyranoski D.
        Alarming COVID variants show vital role of genomic surveillance.
        Nature. 2021; 589: 337-338